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Synthesis of Fe_3O_4@SiO_2@polymer nanoparticles for controlled drug release |
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| Authors: | WU ChengLin HE Huan GAO HongJun LIU Gan MA RuJiang AN YingLi & SHI LinQi Key Laboratory of Functional Polymer Materials Ministry of Education |
| Institution: | WU ChengLin,HE Huan,GAO HongJun,LIU Gan,MA RuJiang,AN YingLi & SHI LinQi Key Laboratory of Functional Polymer Materials,Ministry of Education,Institute of Polymer Chemistry,Nankai University,Tianjin 300071,China |
| Abstract: | Novel multifunctional nanoparticles containing a magnetic Fe3O4@SiO2 sphere and a biocompatible block copolymer poly(ethylene glycol)-b-poly(aspartate)(PEG-b-PAsp) were prepared.The silica coated on the superparamagnetic core was able to achieve a magnetic dispersivity,as well as to protect Fe3O4 against oxidation and acid corrosion.The PAsp block was grafted to the surface of Fe3O4@SiO2 nanoparticles by amido bonds,and the PEG block formed the outermost shell.The anticancer agent doxorubicin(DOX) was loade... |
| Keywords: | magnetic nanoparticle Fe3O4@SiO2 multifunctional controlled drug release |
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