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| 高速毛细管电泳安培法检测甲巯咪唑及其制剂 | |
| 引用本文： | 杨冰仪,张冬梅,莫金垣. 高速毛细管电泳安培法检测甲巯咪唑及其制剂[J]. 分析试验室, 2009, 28(8) |
| 作者姓名： | 杨冰仪 张冬梅 莫金垣 |
| 作者单位： | 1. 广东药学院,广州,510310 2. 中山大学化学与化学工程学院,广州,510275 |
| 基金项目： | 广东省科技计划项目，广东医学院博士科研启动基金 |
| 摘 要： | 采用高速毛细管电泳安培法对甲巯咪唑(TMZ)及其制剂的测定进行了研究; 通过优化检测电位、毛细管长度和内径、分离电压、缓冲溶液等实验参数, TMZ在60 s内可以得到较好的分离, 线性范围在2.00×10-3～2.80×10-5 mol/L, 检出限为3.50×10-6 mol/L; 峰面积和迁移时间的相对标准偏差分别为2.7%、 1.2% (n＝8); 该法可用于制剂中TMZ的检测. |
| 关 键 词： | 高速毛细管电泳 安培检测 甲巯咪唑 |
Determination of thiamazole (TMZ) and its tablets by high-speed capillary electrophoresis with amperometric detection |
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| YANG Bing-yi,ZHANG Dong-mei,MO Jin-yuan. Determination of thiamazole (TMZ) and its tablets by high-speed capillary electrophoresis with amperometric detection[J]. Chinese Journal of Analysis Laboratory, 2009, 28(8) | |
| Authors: | YANG Bing-yi ZHANG Dong-mei MO Jin-yuan |
| Affiliation: | 1.Guangdong College of Pharmacy;Guangzhou 510310;2.School of Chemistry and Chemical Engineering;Sun Yat-sen University;Guanzhou 510275 |
| Abstract: | The characteristic of high-speed capillary electrophoresis(HSCE) lies in the feasibility to improve the separation speed within several seconds or minutes by increasing the voltage and using short length and narrow inner diameter capillary.A method based on high-speed capillary electrophoresis with amperometric detection was developed for the determination of thiamazole(TMZ) and its tablets.The effects of some important factors,such as the detection potential,the length and the inner diameter of capillary,t... |
| Keywords: | High-speed capillary electrophoresis Amperometric detection Thiamazole |
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