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Microwave-assisted one-pot synthesis of benzo[b][1,4]thiazin-3(4H)-ones via Smiles rearrangement |
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| Authors: | Hua Zuo Zhu-Bo Li J.R. Falck Chuljin Ahn |
| Affiliation: | a College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China b Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA c Department of Chemistry, Changwon National University, Changwon, GN 641-733, Republic of Korea |
| Abstract: | The synthesis of benzo[b][1,4]thiazin-3(4H)-one derivatives in a simple and efficient method from the one-pot reaction of substituted 2-chlorobenzenthiols, chloroacetyl chloride, and primary amines via Smiles rearrangement under microwave irradiation gave high yields (65-92%) of the products with short reaction time (15-20 min). |
| Keywords: | Benzo[b][1,4]thiazin-3(4H)-one Microwave Smiles rearrangement 2-Chlorobenzenethiol One-pot |
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