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Tracking growth hormone abuse in sport: A comparison of distinct isoform-based assays |
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| Authors: | J Bosch M Ueki G Such-Sanmartín J Segura R Gutiérrez-Gallego |
| Institution: | 1. Bioanalysis Group, Neuroscience Research Program, IMIM-Parc Salut Mar, Barcelona Biomedical Research Park, Barcelona, Spain;2. Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona Biomedical Research Park, Barcelona, Spain;3. Anti-doping Research Laboratory, Japan Chemical Analysis Center (JCAC), Tokyo, Japan |
| Abstract: | Detecting recombinant human growth hormone (rhGH) abuse in sport remains one of the major challenges in doping control. We have compared two different approaches to detect the hGH (human growth hormone) abuse. The first measures the concentrations of the 22 kDa hGH isoform (rec assay) and pituitary derived isoforms (pit assay) and a ratio rec/pit is obtained. The second measures the concentrations of 22 and 20 kDa hGH isoforms and also a ratio 22/20 kDa is derived. |
| Keywords: | hGH human growth hormone WADA World Anti Doping Agency rhGH recombinant hGH phGH pituitary hGH mAb monoclonal antibody NIBSC National Institute for Biological Standards and Control SPR surface plasmon resonance WOO window of opportunity ILMA immunoluminometric assay LIA luminiscent immuno assay |
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