Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum |
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| Authors: | Suksamrarn Apichart Buaprom Matee Udtip Saifon Nuntawong Nuchnipa Haritakun Rachada Kanokmedhakul Somdej |
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| Institution: | Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand. apichart@ram1.ru.ac.th |
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| Abstract: | From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two new esters, beta-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, beta-sitosterol (4) and stigmasterol (5), were isolated and characterized using spectroscopic methods. Compound 1 exhibited antimycobacterial activity with an MIC value of 25 microg/ml and showed antiplasmodial activity with an IC50 value of 7.2 microg/ml. Compounds 2 and 3 were inactive in both assays. |
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