Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade |
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| Authors: | Rana M. El-Masry Hanan H. Kadry Azza T. Taher Sahar M. Abou-Seri |
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| Affiliation: | 1.Organic Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6th of October City 12451, Egypt;2.Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt; (H.H.K.); (A.T.T.);3.Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, October 6 University (O6U), 6th of October City 12585, Egypt;4.Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt |
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| Abstract: | The bioisosteres of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles are well-known pharmacophores for many medicinally important drugs. Throughout the past 10 years, 1,3,4-oxa-/thiadiazole nuclei have been very attractive to researchers for drug design, synthesis, and the study of their potential activity towards a variety of diseases, including microbial and viral infections, cancer, diabetes, pain, and inflammation. This work is an up-to-date comparative study that identifies the differences between 1,3,4-thiadiazoles and 1,3,4-oxadiazoles concerning their methods of synthesis from different classes of starting compounds under various reaction conditions, as well as their biological activities and structure–activity relationship. |
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| Keywords: | 1,3,4-oxadiazole 1,3,4-thiadiazole bioisosteres synthesis biological activity structure– activity relationship |
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