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Diastereoselective spiroannelation
Affiliation:1. Department of Chemical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK;2. QinetiQ Group PLC, Cody Technology Park, Ively Rd, Farnborough, GU14 0LX, UK;1. College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China;2. Division of Chemistry and Biological Chemistry, Nanyang Technological University, Singapore 637371, Singapore;1. Shenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China;2. Warshel Institute for Computational Biology, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China;3. Academy for Advanced Interdisciplinary Studies and Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China;4. Laboratory of Computational Chemistry and Drug Design, Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China;5. Shenzhen Bay Laboratory, Shenzhen 518055, China;1. Sauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), and College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, China;2. College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China;3. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Abstract:
The diastereoselection in the reaction of 1,4-di-(bromomagnesio) pentane with various structures of lactones and cyclic anhydrides is described.
Keywords:
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