Highly efficient one-pot access to functionalized arylboronic acids via noncryogenic bromine/magnesium exchanges |
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| Authors: | Leermann Timo Leroux Frédéric R Colobert Françoise |
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| Affiliation: | Laboratoire de Stéréochimie (UMR CNRS 7509), CNRS/Université de Strasbourg (ECPM), 25 Rue Becquerel, F-67087 Strasbourg, France. |
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| Abstract: | A general and convenient protocol for the electrophilic borylation of aryl Grignard reagents prepared from arylbromides by direct insertion of magnesium in the presence of LiCl or by Mg/Br exchange with (i)PrMgCl·LiCl has been developed. Various aryl boronic acids were synthesized in a straightforward manner in excellent yields at 0 °C. |
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