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2000 Vol.11 No.8 P.Preparation of AChE Inhibitors From Jujubogenin |
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| Authors: | Yu ZHAO Yuan Ling KU Shoei Sheng LEE |
| Abstract: | A dammarane derivative dihydrojujubogenin-2-en-1-one, which possesses a skeleton and pharmacophore partially similar to those of Territrem B, a potent AChE inhibitor, was synthesized via three different paths. The anti-AChE activity of this compound and related analogue was measured. |
| Keywords: | Alzheimer disease (AD) acetylcholinesterase (AChE) inhibitor pharmaceutical chemistry jujubogenin Territrem B analogues |
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