Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals |
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| Authors: | Ali Fouad Adel A Marzouk Montaser Sh A Shaykoon Samy M Ibrahim Sobhy M El-Adl Ashraf Ghanem |
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| Institution: | 1.Chirality Program, Faculty of Science and Technology, University of Canberra, Bruce, Canberra 2601, Australia;2.Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt; (A.A.M.); (M.S.A.S.);3.Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt; (S.M.I.); (S.M.E.-A.) |
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| Abstract: | Daptomycin, a macrocyclic antibiotic, is here used as a new chiral selector in preparation of chiral stationary phase (CSP) in a recently prepared polymer monolithic capillary. The latter is prepared using the copolymerization of the monomers glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in the presence of daptomycin in water. Under reversed phase conditions (RP), the prepared capillaries were tested for the enantioselective nanoliquid chromatographic separation of fifty of the racemic drugs of different pharmacological groups, such as adrenergic blockers, H1-blockers, NSAIDs, antifungal drugs, and others. Baseline separation was attained for many drugs under RP-HPLC. Daptomycin expands the horizon of chiral selectors in HPLC. |
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| Keywords: | daptomycin monoliths enantioselective nano-HPLC |
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