| 单羟基咔咯锰(III)配合物的合成及其与DNA的相互作用 |
| |
| 引用本文： | 杨文聪,莫婷婷,林泽檀,曾淑莹,方玉琦,江涛,史蕾.单羟基咔咯锰(III)配合物的合成及其与DNA的相互作用[J].合成化学,2017,25(3). |
| |
| 作者姓名： | 杨文聪 莫婷婷 林泽檀 曾淑莹 方玉琦 江涛 史蕾 |
| |
| 作者单位： | 广东第二师范学院 化学系,广东 广州,510303 |
| |
| 基金项目： | 广东省自然科学基金资助项目，广东省本科高校教学质量与教学改革工程专业综合改革项目，广东大学生科技创新培育专项资金，大学生创新创业训练计划项目 |
| |
| 摘 要： | 以五氟苯基二吡咯烷烃为原料,与对羟基苯甲醛经缩合反应合成了单羟基自由咔咯(1);1与醋酸锰反应合成了一种单羟基咔咯锰配合物——10-(4-羟基苯基)-5,15-二(2,3,4,5,6-五氟苯基)咔咯锰(III)配合物,其结构经UV-Vis和HR-MS(ESI)表征.通过紫外滴定、荧光滴定、圆二色谱和琼脂糖凝胶电泳实验探讨了其催化氧化DNA的活性.
|
| 关 键 词： | 五氟苯基二吡咯烷烃 咔咯 锰 DNA 氧化断裂 合成 |
Synthesis of Mono-hydroxyl Corrole Manganese(III) Complex and Its Interaction with DNA |
| |
| YANG Wen-cong,MO Ting-ting,LIN Ze-tan,ZENG Shu-ying,FANG Yu-qi,JIANG Tao,SHI Lei.Synthesis of Mono-hydroxyl Corrole Manganese(III) Complex and Its Interaction with DNA[J].Chinese Journal of Synthetic Chemistry,2017,25(3). |
| |
| Authors: | YANG Wen-cong MO Ting-ting LIN Ze-tan ZENG Shu-ying FANG Yu-qi JIANG Tao SHI Lei |
| |
| Abstract: | Mono-hydroxyl corrole (1) was synthesized by condensation reaction of penta-fluorophenyl dipyrrolidine with p-hydroxybenzaldehyde.10-(4-Hydroxylphenyl)-5,15-bis(2,3,4,5,6-pentafluorophenyl)corrol manganese was synthesized by reaction of 1 with manganese acetate.The structure was characterized by UV-Vis and HR-MS(ESI).The catalytic activity for the oxidation of DNA was tested by UV-Vis, fluorescence spectroscopic studies, circular dichroism spectra and agarose gel electrophoresis. |
| |
| Keywords: | penta-fluorophenyl dipyrrolidine corrole manganese DNA oxidative cleavage synthesis |
| 本文献已被 万方数据 等数据库收录！ |
|
