| Gabriel合成胺反应的工艺改进 |
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| 引用本文： | 王建红,李骞,何丽华,甘莹,王超杰,赵瑾.Gabriel合成胺反应的工艺改进[J].化学研究,2010,21(4):48-51. |
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| 作者姓名： | 王建红 李骞 何丽华 甘莹 王超杰 赵瑾 |
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| 作者单位： | 河南大学,河南省天然药物与免疫工程重点实验室,河南,开封,475004 |
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| 基金项目： | 国家自然科学基金资助项目，河南省科技厅重点科技攻关项目，河南大学省部共建资助项目 |
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| 摘 要： | 采用经典的Gabriel反应合成了直链型多胺骨架,并用1H/13C NMR,MS等方法确证了中间体以及目标化合物的结构.研究表明,在实验条件下,Gabriel反应经历了新的反应历程;经过工艺改进,建立了一条效率较高的工艺路线.
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| 关 键 词： | Gabriel反应 多胺 合成 工艺改进 |
Modification of Process for Synthesizing Polyamine via Gabriel Reaction |
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| WANG Jian-hong,LI Qian,HE Li-hua,GAN Ying,WANG Chao-jie,ZHAO Jin.Modification of Process for Synthesizing Polyamine via Gabriel Reaction[J].Chemical Research,2010,21(4):48-51. |
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| Authors: | WANG Jian-hong LI Qian HE Li-hua GAN Ying WANG Chao-jie ZHAO Jin |
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| Institution: | (Key Laboratory of Natural Medicines and Immuno-engineering,Henan University,Kaifeng 475004,Henan,China) |
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| Abstract: | Classical Gabriel reaction was adopted to synthesize linear polyamine skeleton.The structure of intermidates and target compound were confirmed by means of nuclear magnetic resonance spectroscopy（1H/13C NMR） and mass spectrometry（MS）.Results indicate that under the present test conditions,a new reaction pathway is involved in the Gabriel reaction.By modifying the synthetic process,an efficient route to synthesizing polyamine was established. |
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| Keywords: | Gabriel reaction polyamine synthesis process modification |
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