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| 脱乙酰壳多糖-羧甲基纤维素聚电解质复合物的合成和药物控制释放研究 | |
| 引用本文： | 杨小钢,祝志峰,卓仁禧. 脱乙酰壳多糖-羧甲基纤维素聚电解质复合物的合成和药物控制释放研究[J]. 离子交换与吸附, 1998, 0(4) |
| 作者姓名： | 杨小钢 祝志峰 卓仁禧 |
| 作者单位： | 湖北医科大学(杨小钢)，教育部生物医用高分子材料开放研究实验室!武汉大学化学学院武汉 430072(祝志峰，卓仁禧) |
| 基金项目： | 国家自然科学基金资助课题!（29874028） |
| 摘 要： | 本文研究合成条件对脱乙酰壳多糖－羧甲基纤维素聚电解质复合物的组成、结构及药物控制释放性能的影响。结果表明，反应介质的ｐＨ值对生成的脱乙酰壳多糖－羧甲基纤维素聚电解质复合物的组成和结构的影响最大，在ｐＨ值５．５合成的脱乙酰壳多糖－羧甲基纤维素聚电解质复合物具有较好的药物控释性能。 |
| 关 键 词： | 控制释放 聚电解质复合物 脱乙酰壳多糖 羧甲基纤维素 |
STUDIES ON THE PREPARATION AND DRUG DELIVERY OF CHITOSAN CARBOXYMETHYLCELLULOSE COMPLEXES |
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| Yang Xiaogang, Zhu Zhifeng, Zhuo Renxi. STUDIES ON THE PREPARATION AND DRUG DELIVERY OF CHITOSAN CARBOXYMETHYLCELLULOSE COMPLEXES[J]. Ion Exchange and Adsorption, 1998, 0(4) | |
| Authors: | Yang Xiaogang Zhu Zhifeng Zhuo Renxi |
| Abstract: | A series of polyelectrolyte complexes of chitosan and carboxymethylcellulose had been prepared via polymer interaction. The influence of preparation conditions on the chemical composition and structure of the complexes was studied. The results showed that the pH value of reaction medium was the most important factor among those affecting the composition and structure of the polyelectrolyte complexes formed. The polyelectrolyte complexes thus prepared at different pH were used for the study of controlled release of antitumor drug 5-FU.Better controlled release profile had been obtained in the case of polyelectrolyte complexes prepared at pH5.5. |
| Keywords: | Controlled release Polyelectrolyte complex Chitosan Carboxymethylcellulose |
| 本文献已被 CNKI 等数据库收录！ | |