| 螺[1-氯-4-l-孟氧基-5-氧杂-6-氧代双环[3·1·0]己烷-2,3'-(4'-吗啉基-5'-l-孟氧基丁内酯)]合丙酮的合成及晶体结构 |
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| 引用本文： | 闵凡新,郝向荣,付立海,黄慧,陈庆华.螺[1-氯-4-l-孟氧基-5-氧杂-6-氧代双环[3·1·0]己烷-2,3'-(4'-吗啉基-5'-l-孟氧基丁内酯)]合丙酮的合成及晶体结构[J].结构化学,2004,23(3):342-346. |
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| 作者姓名： | 闵凡新 郝向荣 付立海 黄慧 陈庆华 |
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| 作者单位： | 1. 吉林通化师范学院化学系,134002
2. 北京师范大学化学系,100875 |
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| 基金项目： | 国家自然科学基金(批准号:29672004)资助项目 |
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| 摘 要： | 利用新手性源,5-(l-孟氧基)-3-氯-2(5H)-呋喃酮4与亲核试剂吗啉通过串联不对称双Michael加成/分子内亲核取代反应合成了一般方法难以得到的含有多个手性中心的螺-环丙烷双内酯化合物C32H50O7NCl.其单晶为C32H50O7NCl(OC3H6)0.5,正交晶系, 空间群为P212121, 晶胞参数a = 17.149(3), b = 20.384(4), c = 10.831(2) , V = 3786.1(12) 3, Z = 4, Dc = 1.097 g/cm3, F(000) = 1352, μ= 0.144 mm-1; 射线类型为MoK?( = 0.71073 ?, 偏离因子R = 0.0755, wR = 0.1956, 独立衍射点3710个, 其中可观测点数2318个.分子中共有六个环, 12个手性中心, 3个六元环呈椅式构象, 两个五员内酯环呈信封式构象, 并分别与环丙烷形成2.4]螺环和 3.1.0] 稠环, 4个新生成的手性中心的绝对构型为C(3)(S), C(4)(S), C(5)(R), C(8)(R).
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| 关 键 词： | 手性源 3-氯-2(5H)-呋喃酮 螺-环丙烷双内酯化合物 晶体结构 |
Synthesis and Crystal Structure of Sprio[5-l-menthyloxy-3-hlorobutyrolacto-cyclopropane-2,3'-(4'-morpholin-4-yl-5'-menthyloxy-butyrolactone)] and Acetone |
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| MIN Fan-Xin,HAO Xiang-Rong,FU Li-Hai,HUANG Hui,CHEN Qing-Hua.Synthesis and Crystal Structure of Sprio[5-l-menthyloxy-3-hlorobutyrolacto-cyclopropane-2,3''''-(4''''-morpholin-4-yl-5''''-menthyloxy-butyrolactone)] and Acetone[J].Chinese Journal of Structural Chemistry,2004,23(3):342-346. |
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| Authors: | MIN Fan-Xin HAO Xiang-Rong FU Li-Hai HUANG Hui CHEN Qing-Hua |
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| Abstract: | The synthesis and crystal structure of the title compound C32H50O7NCl?OC3H6)0.5 is reported herein. The complex crystallizes in orthorhombic, space group P212121 with a = 17.149(3), b = 20.384(4), c = 10.831(2) ? Mr = 625.22, V = 3786(12) 3, Z = 4, Dc = 1.097 g/cm3, F(000 )= 1352, ?= 0.144 mm-1, the final R = 0.0755 and wR = 0.1956. The compound contains 6 rings and 12 chiral centers. |
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| Keywords: | spiro-cyclopropane derivatives synthesis crystal structure absolute configuration |
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