Ligand‐free CuTC‐catalyzed N‐arylation of amides,anilines and 4‐aminoantipyrine: synthesis of N‐arylacrylamides, 4‐amido‐N‐phenylbenzamides and 4‐amino(N‐phenyl)antipyrenes |
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| Authors: | Zheng‐Jun Quan Hai‐Dong Xia Zhang Zhang Yu‐Xia Da Xi‐Cun Wang |
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| Institution: | 1. Key Laboratory of Eco‐Environment‐Related Polymer Materials, Ministry of Education of China, Gansu, People's Republic of China;2. Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Gansu, People's Republic of China |
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| Abstract: | N‐Arylation of amides and anilines with aryl iodides was efficiently catalyzed by copper thiophenecarboxylate under ligand‐free conditions with good to excellent yields. A variety of substituted aryl iodides, amides, anilines and 4‐aminoantipyrine were found to be applicable to the simple catalytic system. Furthermore, some practical, unique secondary amides, such as N‐arylacrylamides and 4‐amido‐N‐phenylbenzamides, and 4‐amino(N‐phenyl)antipyrenes, which are difficult to obtain by the classical methods, were prepared. Copyright © 2013 John Wiley & Sons, Ltd. |
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| Keywords: | CuTC N‐arylation amides anilines aryl iodides |
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