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| 电喷雾质谱技术研究反应条件对三种含硫氨基酸自组装成肽的影响 | |
| 引用本文： | 李锐,卢奎,马丽,曹书霞,赵玉芬.电喷雾质谱技术研究反应条件对三种含硫氨基酸自组装成肽的影响[J].分析试验室,2007,26(9):21-26. |
| 作者姓名： | 李锐 卢奎 马丽 曹书霞 赵玉芬 |
| 作者单位： | 1. 河南工业大学化学化工学院,郑州,450052 2. 郑州大学化学系化学生物学重点实验室,郑州,450052 3. 郑州大学化学系化学生物学重点实验室,郑州,450052;清华大学生命科学与工程研究院化学系生命有机磷化学教育部重点实验室,北京,100084 |
| 基金项目： | 国家自然科学基金 , 河南省杰出青年科学基金 , 河南省教育厅科技计划 |
| 摘 要： | 研究了三氯氧磷辅助下3种含硫氨基酸的自组装成肽反应,利用电喷雾质谱技术,考察了反应时间、温度和溶剂对3种含硫氨基酸成肽反应的影响,比较了三氯氧磷辅助下3种含硫氨基酸成肽的反应活性.可为寡肽的合成提供一种新的方法. |
| 关 键 词： | 电喷雾质谱 含硫氨基酸 自组装成肽 |
| 文章编号： | 1000-0720（2007）09-021-06 |
| 修稿时间： | 2006-08-19 |
Monitoring influence of reaction conditions on self-assembly into olig-peptides for three sulf-amino acids by using ESI-MS |
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| LI Rui,LU Kui,MA Li,CAO Shu-xia,ZHAO Yu-fen.Monitoring influence of reaction conditions on self-assembly into olig-peptides for three sulf-amino acids by using ESI-MS[J].Chinese Journal of Analysis Laboratory,2007,26(9):21-26. | |
| Authors: | LI Rui LU Kui MA Li CAO Shu-xia ZHAO Yu-fen |
| Institution: | 1. School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450052; 2. Department of Chemistry, Zhengzhou University, Zhengzhou 450052; 3. The Key Laboratory for Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084 |
| Abstract: | In this paper,the phosphorylation of three sulf-amino acids and the self-assembly into oligo-peptides mediated by phosphorus oxychloride were studied by using electrospray ionization mass spectrometry(ESI-MS).On quenching with water, the reaction mixtures,which were produced under different reaction conditions, yielded the corresponding peptides.Influence of the reaction conditions such as reaction time,solvent and temperature on self-assembly into olig-peptides for three sulf-amino acids were monitored.Also,the assembled oligo-peptides activity of three sulf-amino acids were discussed. |
| Keywords: | ESI-MS Sulf-amino acids Self-assembly into oligo-peptides |
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