Total synthesis of stagonolide B |
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Authors: | Tapas DasTridib Mahapatra Samik Nanda |
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Institution: | Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India |
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Abstract: | Asymmetric total synthesis of nonenolide stagonolide-B has been presented in this Letter. The main highlight of our synthetic strategy is the application of hydroxynitrile lyase (ParsHNL) mediated asymmetric synthesis of cyanohydrin, Sharpless asymmetric dihydroxylation, cross metathesis (CM) reaction, stereoselective Keck allylation reaction and Yamaguchi macrolactonization at a late stage enables us to achieve the synthesis of the target molecule in an efficient way. |
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Keywords: | Small ring macrolide Enzymatic hydrocynation Asymmetric allylation Cross metathesis Macrolactonization |
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