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Characterization of (16R) and (16S)-hydroxyroquefortine C; diastereomeric metabolites from Penicillium crustosum DAOM 215343 |
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| Authors: | Laird A TrimbleMark W Sumarah Barbara A BlackwellMark D Wrona J David Miller |
| Institution: | a Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe Claire Dorval, Quebec, Canada H9H 4P8 b Department of Chemistry, Carleton University, 1125 Colonel By Drive, Steacie Building, Ottawa, Ontario, Canada K1S 5B6 c Eastern Cereal and Oilseed Research Centre, 960 Carling Avenue, Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada K1A 0C6 |
| Abstract: | Two diastereomeric metabolites (16R) and (16S)-hydroxyroquefortine C were characterized from Penicillium crustosum DAOM 215343. The 16S metabolite is reported for the first time along with evidence for the absolute stereochemistry of both. The metabolites were originally detected by LC-NMR and the structures of the subsequently isolated metabolites were elucidated by HRMS and NMR. |
| Keywords: | Roquefortine C Penicillium crustosum Cattle toxicosis LC-NMR |
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