Enantioselective synthesis of nitrocyclopropanes via conjugate addition of bromomalonate to nitroalkenes catalyzed by Ni(II) complexes |
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Authors: | Hyun Joo LeeSun Mi Kim Dae Young Kim |
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Institution: | Department of Chemistry, Soonchunhyang University, Asan, Chungnam 336-745, Republic of Korea |
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Abstract: | A novel one-pot methodology for the catalytic enantioselective synthesis of highly functionalized nitrocyclopropanes promoted by chiral nickel complexes is developed. The treatment of bromomalonates with nitroalkenes under the mild reaction conditions afforded the corresponding Michael adducts which cyclizes to controlled reaction conditions with excellent diasteroselectivities (>99 de) and enantioselectivities (up to 99% ee). |
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Keywords: | Cyclopropanation Asymmetric catalysis Chiral nickel catalysts Nitroalkenes Conjugate addition |
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