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Synthesis and characterization of a newly designed di-copper(II)-based complex and study of its artificial enzyme catalytic activity |
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| Authors: | H Derakhshankhah A A Saboury A Divsalar H Mansouri-Torshizi I Bamery D Ajloo A A Moosavi-Movahedi R Hosseinzadeh M R Ganjali H Ilkhani H R Khavasi |
| Institution: | 1. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran 2. Center of Excellence in Biothermodynamics, University of Tehran, Tehran, Iran 3. Department of Biological Sciences, Tarbiat Moallem University, Tehran, Iran 4. Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran 5. School of Chemistry, Damghan University, Damghan, Iran 6. Academic Center for Education, Culture and Research, Urmia Branch, University of Urmia, Urmia, Iran 7. Department of Chemistry, University of Tehran, Tehran, Iran 8. Department of Chemistry, Shahid Beheshti University, Evin, Tehran, Iran |
| Abstract: | A di-copper(II) complex of the formula (dien)Cu(μ-1,6-DAH)Cu(dien)(NO3)2](NO3)2, where μ-1,6-DAH = 1,6-diaminohexane, has been synthesized and characterized by X-ray crystallography, X-ray powder diffraction, thermal gravimetric (TG) and differential thermal analyses, cyclic voltammetry, infrared, ultraviolet visible spectroscopies and elemental analysis methods. It was crystallized in a monoclinic system, space group P21/n, with a = 8.0297(8) Å, b = 12.4937(14) Å, c = 15.3786(15) Å, β = 102.739(8) Å and z = 2. Each copper(II) has a square-based pyramidal coordination geometry with four N atoms building the basal plane (three from dien and one from μ-1,6-DAH). TGA study of the complex revealed the compound to be stable up to 245 °C. Electrochemical behavior of complex and enzyme-like catalytic activity of this complex, as a potential functional model for the active site of tyrosinase, was studied extensively. Kinetic studies show that the complex has the maximum enzymatic activity at pH 8, temperature of 40 °C and ionic strength of 50 mM. |
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