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Dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle |
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| Authors: | Yan-Hui Liu Ying-Bing Chen Wei Mao Lin Hu Lin-Hong Deng Hou-Qiang Xu |
| Institution: | 1. Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region Ministry of Education, College of Animal Science, Guizhou University, Guiyang, 550025, China 2. Soft Condensed Matter Laboratory, College of Science, Guizhou University, Guiyang, 550025, China 3. State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing, 100190, China 4. Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, 213164, China 5. Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, 400044, China |
| Abstract: | Recent experiments have pointed out that cellular uptake is strongly dependent on the physical dimensions of endocytosed nanoparticles and the optimal radius of endocytosed virus-like particle coated by transferrin is around 50 nm. As the same time, the dimensions of receptor-ligand complex have strong effects on the size-dependent exclusion of proteins in cell environments. Inspired by these experimental results, a continuum elastic model is constructed to resolve the relationship between the dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle. These results demonstrate that the optimal radius of endocytosed virus-like particle depends on the dimensions of receptor-ligand complex and the dimension of receptor-ligand complex reduces the depletion zone. |
| Keywords: | cellular uptake depletion effects dimension of receptor-ligand complex elasticitytheory |
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