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Chiral Separation of 4-Iminoflavan Derivatives on Several Polysaccharide-Based Chiral Stationary Phases by HPLC |
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| Authors: | Ismahan Rahou Nasser Belboukhari Khaled Sekkoum Abdelkarim Cheriti Hassan Y Aboul-Enein |
| Institution: | 1. Bioactive Molecules and Chiral Separation Laboratory, Faculty of Science and Technology, University of Bechar, Bechar, Algeria 2. Phytochemistry and Organic Synthesis Laboratory, Faculty of Science and Technology, University of Bechar, Bechar, Algeria 3. Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Center, Dokki, Cairo, Egypt |
| Abstract: | The HPLC enantiomeric separation of seven 4-iminoflavans was successfully accomplished in the normal phase mode using six polysaccharide-based chiral stationary phases namely, Chiralcel®OD-H, Chiralcel®OD, Chiralcel®OJ, Chiralpak®AD, Chiralpak®IA and Chiralpak®IB under normal and polar organic phase modes. The resolution depended on nature and concentration of alcoholic modifier. The results demonstrate clearly that the chromatographic system based on the coated and immobilized type Chiralpak®IB and Chiralcel®OD-H CSPs provide a powerful analytical tool for enantiomeric separation of all the 4-iminoflavans used in this study. |
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