Novel N,N,P-tridentate ligands for the highly enantioselective copper-catalyzed 1,4-addition of dialkylzincs to enones |
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| Authors: | Kawamura Kenjiro Fukuzawa Hitomi Hayashi Masahiko |
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| Affiliation: | Department of Chemistry, Graduate School of Science, Kobe University, Kobe 657-8501, Japan. |
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| Abstract: | ![]()
Use of 0.25 mol % of the N, N, P-tridentate ligand containing the 2-quinolyl moiety ( 1 and 2) and 0.1 mol % of Cu(OTf) 2 enabled the enantioselective 1,4-addition of dialkylzincs to cyclic enones to produce 1,4-adducts in up to 99% ee. |
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