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Two New Alkaloids from Stemona tuberosa
Authors:Ying Zhong  Ying Gao  Qiu‐Ping Guo  Wei‐Min Li
Affiliation:1. Research and Development Center of New Drugs, Guangzhou University of Chinese Medicine, Guangzhou 510006, P.?R. China;2. College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou Higher Education Mega Center, Guangzhou 510006, P.?R. China, (phone: +86‐20‐39358290;3. fax: +86‐20‐87470715)
Abstract:
Two new alkaloids, named tuberostemoninol A ( 1 ) and tuberostemoninol B ( 2 ), along with the known compounds tuberostemoninol ( 3 ) and bisdehydroneotuberostemonine ( 4 ), were isolated from Stemona tuberosa Lour . The structures were elucidated by means of spectroscopic analyses, including 1D‐ and 2D‐NMR experiments. The four alkaloids 1 – 4 were analyzed by on‐line high‐performance liquid chromatography/electrospray‐ionization mass spectrometry (HPLC/ESI‐MS), and their fragmentation pathways were found to be similar. Compounds 1, 2 , and 3 are isomers with the same molecular mass but which eluted at different retention times.
Keywords:Stemona tuberosa  Alkaloids  Tuberostemoninols A and B  Neotuberostemonine
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