Structural polymorphism analysis of Chinese Mongolian ethnic group revealed by a new STR panel: Genetic relationship to other groups |
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| Authors: | Chun‐Mei Shen Hua Wu Guo‐lian Yuan Li‐Jun Zhao Jiang‐Wei Yan Hao‐Tian Meng Yu‐Dang Zhang Wen‐Juan Liu Hong‐Dan Wang Richard E White Xing Wei |
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| Institution: | 1. Blood Center of Shaanxi Province, Xi'an, P. R. China;2. Xi'an Child Hospital, Xi'an, P. R. China;3. Scientific Research and Experiment Center, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, P. R. China;4. Department of Pathophysiology, Basic Medical College, Hebei United University, Tangshan, P. R. China;5. Beijing Institute of Genomics, Chinese Academy of Science, Beijing, China;6. School of Medicine, Xi'an Jiaotong University, Xi'an, P. R. China;7. Medical Genetic Institute of Henan Province, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, P. R. China;8. Department of Pharmacology & Toxicology, Georgia Health Sciences University, Augusta, GA, USA;9. Department of Trauma Orthopedics, Xi'an Hong‐hui Hospital, Xi'an, China;10. Department of Trauma Orthopedics, Hong‐hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, China |
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| Abstract: | Mongolian is the eighth largest ethnic minority on Chinese population data according to the 2010 census. In the present study, we presented the first report about the allelic frequencies and forensic statistical parameters at the 21 new STRs and analyzed linkage disequilibrium of pairwise loci in the Mongolian ethnic minority, China. Hardy–Weinberg equilibrium tests demonstrated no significant deviations except for the D1S1627 locus. The cumulative power of discrimination and power of exclusion of all the loci are 0.9999999999999999992576 and 0.9999997528, respectively. The results of analysis of molecular variance showed that significant differences between the Mongolian and the other eight populations were found at 1‐9 STR loci. In population genetics, the results of principal component analysis, structure analysis, and phylogenetic reconstruction analysis indicated shorter genetic distance between the Mongolian group and the Ningxia Han. All the results suggest that the 21 new STR loci will contribute to Chinese population genetics and forensic caseworks in the Mongolian group. |
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| Keywords: | Mongolian STR Structural Polymorphisms |
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