Amine-catalyzed coupling of allenic esters to alpha,beta-unsaturated carbonyls |
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| Authors: | Evans Catherine A Miller Scott J |
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| Affiliation: | Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467-3860, USA. |
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| Abstract: | Nucleophilic amines catalyze the 1,4-addition of allenic esters to alpha,beta-unsaturated carbonyl compounds. The reactions proceed under mild conditions. In addition, Baylis-Hillman products serve as appropriate electrophiles for the process such that a one-pot, three-component coupling of aldehydes, acrylates, and allenic esters may be achieved. |
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