| Pd/C催化的对异丁基苯乙酮加氢反应 |
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| 引用本文： | 陈瑞芳,刘春,肖启民,金子林.Pd/C催化的对异丁基苯乙酮加氢反应[J].催化学报,1999,20(4):471-474. |
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| 作者姓名： | 陈瑞芳 刘春 肖启民 金子林 |
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| 作者单位： | 大连理工大学精细化工国家重点实验室,大连,116012 |
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| 基金项目： | 辽宁省国际合作基金;97704028; |
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| 摘 要： | ２（４异丁基苯基）丙酸（俗称布洛芬）是一种重要的解热镇痛消炎药物［１］，经典的生产路线是由异丁基苯出发，经弗克反应、达村缩合，最后经氧化制得［２］；其合成步骤多，成品精制难，生产成本高．美国于１９９２年通过１（４异丁基苯基）乙醇（ＩＢＰＥ）羰...
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| 关 键 词： | Pd C 加氢 动力学 精细化工 均相催化 |
| 收稿时间： | 1999-08-25 |
STUDY ON HYDROGENATION OF p-ISOBUTYLACETOPHENONE OVER Pd/C CATALYST |
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| Chen Ruifang,Liu Chun,Xiao Qimin,Jin Zilin.STUDY ON HYDROGENATION OF p-ISOBUTYLACETOPHENONE OVER Pd/C CATALYST[J].Chinese Journal of Catalysis,1999,20(4):471-474. |
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| Authors: | Chen Ruifang Liu Chun Xiao Qimin Jin Zilin |
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| Abstract: | In this paper, the effects of NaOH amount, reaction temperature, catalyst concentration and hydrogen pressure on the hydrogenation of pisobutyl acetophenone (IBAP) over 5% Pd/C are investigated in detail. The optimum reaction conditions are as follows: p (H2) =09 MPa, T=303 K, m (5%Pd/C) =04 g, and m (NaOH) =008 g. The conversion of IBAP and the yield of 1(4isobutylphenyl)ethanol (IBPE) are 995% and 958%, respectively. The hydrogenation reaction follows the first order kinetics with respect to IBAP concentration, catalyst concentration and hydrogen pressure, respectively. The activation energy for this reaction is ca 422 kJ/mol. |
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| Keywords: | isobutyl acetophenone isobutyl phenylethanol hydrogenation palladium activated carbon |
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