| 离子液体中酶促Michael加成反应的研究 |
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| 引用本文： | 魏晓飞,杜创,王任,苗卿华,王萍,李春元,王智,王磊.离子液体中酶促Michael加成反应的研究[J].分子催化,2009,23(3). |
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| 作者姓名： | 魏晓飞 杜创 王任 苗卿华 王萍 李春元 王智 王磊 |
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| 作者单位： | 1. 吉林大学,分子酶学工程教育部重点实验室,吉林,长春,130023
2. 中国科学院,长春光学精密机械与物理研究所,激发态物理重点实验室,吉林长春,130031 |
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| 基金项目： | 国家自然科学基金，吉林省科技发展计划青年科研基金 |
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| 摘 要： | 以离子液体作为反应介质,研究了嗜热酯酶APE1547在不同离子液体中催化咪唑与丙烯酸乙酯的Mi-clasel加成反应,并对反应条件进行了优化.在最适反应条件下,Michael加成反应产率可达98.8%,另外发现嗜热酯酶APE1547在该反应体系中可重复使用8次,其催化性能没有明显下降.
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| 关 键 词： | 嗜热酯酶 离子液体 Michael加成 丙烯酸乙酯 咪唑 |
Study on the Enzymatic Michael Addition in Ionic Liquids |
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| WEI Xiao-fei,DU Chuang,WANG Ren,MIAO Qing-hu,WANG Ping,LI Chun-yuan,WANG Zhi,WANG Lei.Study on the Enzymatic Michael Addition in Ionic Liquids[J].Journal of Molecular Catalysis (China),2009,23(3). |
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| Authors: | WEI Xiao-fei DU Chuang WANG Ren MIAO Qing-hu WANG Ping LI Chun-yuan WANG Zhi WANG Lei |
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| Institution: | 1.Jilin University Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education;Changchun 130023;China;2.Changchun Institute of Optics;Fine Mechanics and Physics Chinese Academy of Sciences;Changchun 130031;China |
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| Abstract: | The catalytic performance of thermophilic esterase APE1547 on the enzymatic Michael addition was investigated when different ionic liquids were used as reaction media.The optimum conditions were screened out with yield of up to 98.8%.The reaction system can be used 8 times and no significant decrease in catalytic performance. |
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| Keywords: | Thermophilic esterase Ionic liquid Michael addtion Ethyl acrylate Imidazole |
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