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A facile synthesis of (S)-(−)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine by zinc chloride assisted mitsunobu cyclization reaction |
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| Authors: | Soon Bang Kang Eu Jin Ahn Youseung Kim Yong Hae Kim |
| Affiliation: | Division of Applied Science, Korea Institute of Science and Technology, Cheongryang P.O. Box 131, Seoul 130-650, Korea Department of Chemistry, Korea Advanced Institute of Science and Technology, Taejon 305-701, Korea |
| Abstract: | A convenient procedure for preparation of the title compound of ≥99% ee starting from 1-(2,3-difluoro-6-nitrophenoxy)-2-propanone (3) is presented. The key reaction is the intramolecular cyclization reaction in the presence of zinc chloride. |
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