| 人工核酸酶的设计和与核酸的相互作用 |
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| 引用本文： | 张晶晶,邵莺,韦丽,李英,盛欣,刘芳,陆国元.人工核酸酶的设计和与核酸的相互作用[J].中国科学B辑,2009,39(3):194-207. |
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| 作者姓名： | 张晶晶 邵莺 韦丽 李英 盛欣 刘芳 陆国元 |
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| 作者单位： | 南京大学化学化工学院;配位化学国家重点实验室; |
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| 基金项目： | 国家自然科学基金(批准号:20872061,20372032);;国家重点基础研究发展计划(编号:2007CB925103)项目资助 |
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| 摘 要： | 人工核酸酶在基因药物设计和分子生物学研究领域具有重要的科学意义，因此人工核酸酶的设计和酶模拟方面的研究引起了广泛关注并取得了重要进展．本文介绍近年来国内外学者和作者研究组在“双功能协同催化”、“双核协同催化”、“无金属催化”的人工核酸酶方面的研究进展，尤其是氮杂冠醚衍生物作为人工核酸酶与DNA相互作用的研究进展．
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| 关 键 词： | 人工核酸酶 DNA切割 无金属切割DNA 胍基 氮杂冠醚 |
| 收稿时间： | 2008-11-03 |
| 修稿时间： | 2008-12-02 |
Design of artificial nucleases and studies of their interaction with DNA |
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| ZHANG JingJing,SHAO Ying,WEI Li,LI Ying,SHENG Xin,LIU Fang & LU GuoYuan State Key Laboratory of Coordination Chemistry.Design of artificial nucleases and studies of their interaction with DNA[J].Science in China(Series B),2009,39(3):194-207. |
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| Authors: | ZHANG JingJing SHAO Ying WEI Li LI Ying SHENG Xin LIU Fang & LU GuoYuan State Key Laboratory of Coordination Chemistry |
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| Institution: | ZHANG JingJing,SHAO Ying,WEI Li,LI Ying,SHENG Xin,LIU Fang & LU GuoYuan State Key Laboratory of Coordination Chemistry,Department of Chemistry,Nanjing University,Nanjing 210093,China |
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| Abstract: | The design of artificial nucleases and nuclease mimics has attracted extensive attention and made great progress due to their significant scientific meanings and potential application in the field of gene medicine and mo-lecular biology. This paper reviews recent progress in the investigation of artificial nuclease, including "bifunctional cooperative catalysis", "dinuclear synergistic catalysis", "metal-free catalysis", and especially, the studies of aza-crown ethers as artificial nucleases and their inter... |
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| Keywords: | artificial nuclease DNA cleavage metal-free cleavage DNA guanidinium group aza-crown ether |
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