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Synthetic studies towards ptilomycalin A: total synthesis of crambescidin 359 |
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| Authors: | Christopher G. Moore Harri L. Williams Nigel K. Smith |
| Affiliation: | a Department of Chemistry, University of Wales, Bangor, Gwynedd LL57 2UW, UK b Christie CRC Research Centre, Paterson Institute for Cancer Research, Christie NHS Trust, Wilmslow Road, Manchester M20 4BX, UK |
| Abstract: | A potentially biomimetic synthesis of the guanidine-containing marine natural product crambescidin 359 via a double Michael addition of guanidine to a suitably functionalised bis-enone is reported. |
| Keywords: | Crambescidin 359 Ptilomycalin A Guanidine Michael addition |
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