Die Synthese von 6,7-Dihydro-2H-pyrimido[6, 1-a]isochinolin-4(3H)-onen und analogen Verbindungen und deren Wirkung als Blutpättchenaggregationshemmer

Synthesis of 6,7-Dihydro-2H-pyrimido6,1-a]isoquinolin-4(3H)-ones and Analogous Compounds and their Activity as Blood-Platelet Inhibitors The synthesis of 6,7-dihydro-2H-pyrimido6,1-a]isoquinolin-4(3H)-ones and of analogous compounds is described. These compounds are powerful phosphodiesterase inhibitors and, therefore, inhibit blood-platelet aggregation independent of the agonist. They exhibit, too, cardiac activities. However, there is evidence for selective action. A structure-activity relationship for platelet-aggregation inhibitors is discussed.