Biocompatible, surface functionalized mesoporous titania nanoparticles for intracellular imaging and anticancer drug delivery |
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Authors: | Wu Kevin C-W Yamauchi Yusuke Hong Chen-Yu Yang Ya-Huei Liang Yung-He Funatsu Takashi Tsunoda Makoto |
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Affiliation: | Department of Chemical Engineering, National Taiwan University. No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. kevinwu@ntu.edu.tw |
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Abstract: | Mesoporous titania nanoparticles (MTNs) with excellent biocompatibility (LC(50)≈ 400 μg mL(-1)) and a large surface area (ca. 237.3 m(2) g(-1)) were synthesized and further functionalized with a phosphate-containing fluorescent molecule (i.e. flavin mononucleotide; FMN) and loaded with an anticancer drug (i.e. Doxorubicin) for successful intracellular bioimaging and drug delivery, respectively, in human breast cancer cells BT-20. |
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