A highly specific BODIPY-based fluorescent probe for the detection of hypochlorous acid |
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| Authors: | Sun Zhen-Ning Liu Feng-Qin Chen Yan Tam Paul Kwong Hang Yang Dan |
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| Affiliation: | Department of Chemistry, The University of Hong Kong, Hong Kong, P.R. China. |
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| Abstract: | A fluorescent probe, HKOCl-1, has been successfully developed for the detection of hypochlorous acid on the basis of a specific reaction with p-methoxyphenol. The formation of HOCl has been successfully detected not only in an abiotic system but also in an enzymatic system (myeloperoxidase/H2O2/Cl(-) system) and in living macrophage cells upon stimulation. This new probe might be used as an efficient tool for probing the roles HOCl plays in biological systems. |
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