| 可回收手性配体[QN（OH）2]2PHAL催化合成紫杉醇13-C侧链 |
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| 引用本文： | 南鹏娟,赵海康,陈晶,崔新爱. 可回收手性配体[QN（OH）2]2PHAL催化合成紫杉醇13-C侧链[J]. 合成化学, 2012, 0(3): 356-358,383 |
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| 作者姓名： | 南鹏娟 赵海康 陈晶 崔新爱 |
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| 作者单位： | 陕西师范大学材料科学与工程学院;西安医学院第二附属医院 |
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| 基金项目： | 国家自然科学基金资助项目(20973105) |
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| 摘 要： | 在可回收手性配体[QN(OH)2]2PHAL的催化下,通过不对称氨羟化或双羟化反应合成紫杉醇13-C侧链,两种方法的产率分别为39%,97%ee和52%,99%ee,其结构经1H NMR,IR和元素分析确证。
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| 关 键 词： | 不对称双羟化反应 不对称氨羟化反应 可回收手性配体 紫杉醇13-C侧链 合成 |
Synthesis of Taxol 13-C Side Chain Catalyzed by Recoverable Chiral Ligand |
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| NAN Peng-juan,ZHAO Hai-kang,CHEN Jing,CUI Xin-ai. Synthesis of Taxol 13-C Side Chain Catalyzed by Recoverable Chiral Ligand[J]. Chinese Journal of Synthetic Chemistry, 2012, 0(3): 356-358,383 |
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| Authors: | NAN Peng-juan ZHAO Hai-kang CHEN Jing CUI Xin-ai |
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| Affiliation: | 1(1.School of Materials Science and Engineering,Shaanxi Normal University,Xi’an 710062,China; 2.The Second Affiliated Hospital,Xian Medical University,Xi’an 710038,China) |
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| Abstract: | The taxol 13-C side chain was synthesized by asymmetric aminohydroxylation or dihydroxylation of trans-cinnamate using recoverable and resued chiral ligand 2PHAL as the catalyst.The structures were confirmed by 1H NMR,IR and elemental analysis.The yields were 39% with 97%ee and 52% with 99%ee,respectively by two methods. |
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| Keywords: | asymmetric dihydroxylation asymmetric aminohydroxylation recoverable chiral ligand taxol 13-C side chain synthesis |
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