Cobalt‐Catalyzed Allylation of Heterobicyclic Alkenes: Ligand‐Induced Divergent Reactivities |
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Authors: | Yuan Huang Chao Ma Yi Xin Lee Rui‐Zhi Huang Prof Yu Zhao |
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Institution: | Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore) zhaoyu.science.nus.edu.sg |
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Abstract: | The allylation of heterobicyclic alkenes is presented for the first time. By using an inexpensive cobalt salt as the catalyst and easy‐to‐handle potassium allyltrifluoroborate as the reagent, an unprecedented formal hydroallylation of the bicyclic alkenes is realized in high efficiency. When a chiral cobalt/bis(phosphine) complex is used instead, the alternative ring‐opening products can be obtained in high yield and excellent enantioselectivity. |
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Keywords: | alkenes allylic compounds cobalt P ligands synthetic methods |
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