Tandem Chemoselective Suzuki–Miyaura Cross‐Coupling Enabled by Nucleophile Speciation Control |
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| Authors: | Ciaran P. Seath James W. B. Fyfe John J. Molloy Dr. Allan J. B. Watson |
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| Affiliation: | WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL (UK) |
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| Abstract: | Control of boronic acid speciation is presented as a strategy to achieve nucleophile chemoselectivity in the Suzuki–Miyaura reaction. Combined with simultaneous control of oxidative addition and transmetalation, this enables chemoselective formation of two C? C bonds in a single operation, providing a method for the rapid preparation of highly functionalized carbogenic frameworks. |
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| Keywords: | boron chemoselectivity cross‐coupling palladium speciation |
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