| 基于~1H NMR代谢组学方法的糖尿病溃疡组织代谢特征和病理机制分析 |
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| 引用本文： | 谢丽云,宋才勇,娄依依,徐志,张美玲,董柏君,高红昌,李校堃.基于~1H NMR代谢组学方法的糖尿病溃疡组织代谢特征和病理机制分析[J].化学学报,2011,69(19):2265-2271. |
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| 作者姓名： | 谢丽云 宋才勇 娄依依 徐志 张美玲 董柏君 高红昌 李校堃 |
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| 作者单位： | 1. 温州医学院药学院,温州,325035
2. 上海交通大学医学院附属仁济医院泌尿科,上海,200127 |
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| 基金项目： | 国家自然科学基金(Nos.21175099,30872961); 浙江省医药卫生专项(No.2010QNA016)资助项目 |
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| 摘 要： | 糖尿病溃疡是临床上导致患者截肢的最主要原因,应用基于1H NMR的代谢组学方法研究了链脲佐菌素（STZ）诱导的SD糖尿病大鼠溃疡组织的代谢轮廓,同时结合组织病理和生化分析,阐述了糖尿病溃疡组织的代谢特征和病理机制.结果表明,糖尿病大鼠在溃疡组织愈合过程中的成纤维细胞增殖和毛细血管增生都明显弱于对照组;代谢组学分析的散点...
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| 关 键 词： | 糖尿病溃疡 1H NMR 病理机制 皮肤组织 |
Studies on Metabolic Characteristics and Pathological Mechanisms of Diabetic Ulcers by ~1H NMR-based Metabonomics |
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| Xie,Liyuna Song,Caiyonga Lou,Yiyi a Xu,Zhi a Zhang,Meilinga Dong,Baijunb Gao,Hongchang,a Li,Xiaokuna.Studies on Metabolic Characteristics and Pathological Mechanisms of Diabetic Ulcers by ~1H NMR-based Metabonomics[J].Acta Chimica Sinica,2011,69(19):2265-2271. |
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| Authors: | Xie Liyuna Song Caiyonga Lou Yiyi a Xu Zhi a Zhang Meilinga Dong Baijunb Gao Hongchang a Li Xiaokuna |
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| Institution: | Xie,Liyuna Song,Caiyonga Lou,Yiyi a Xu,Zhi a Zhang,Meilinga Dong,Baijunb Gao,Hongchang,a Li,Xiaokuna(a School of Pharmacy,Wenzhou Medical College,Wenzhou 325035)(b School of Medicine,Shanghai Jiao Tong University,Shanghai 200127) |
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| Abstract: | Diabetic ulcer is the most important factor leading to clinical amputation.In the present study, 1H NMR-based metabonomics combined with pathological and biochemical analysis were used to study the metabolic characteristics and pathological mechanisms of diabetic ulcers.The results showed that the fibroblast and blood capillaries proliferation in skin ulcers of diabetic rats were significantly weaker than those in the control rats.From the scores plots of metabonomic studies,we found distinct,easily detecta... |
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| Keywords: | diabetic ulcer 1H NMR pathological mechanisms skin tissue |
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