| Design and Synthesis of Lipids Bearing Nucleosides as Gene Vectors |
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| 作者姓名： | Man Zhou ZHU Qi Hua WU Qing Xiang GUO* |
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| 作者单位： | Man Zhou ZHU，Qi Hua WU，Qing Xiang GUO* Department of Chemistry，University of Science and Technology of China，Hefei 230026 |
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| 摘 要： | Delivery of exogenous DNA into cells of various origins plays an important role not only in basic research, but also in clinical application in gene therapy. Great efforts have been made towards the development of viral and nonviral vectors for these purposes1~6. However, at the present stage, none of the vectors can claim to be the panacea. Although most viral vectors can transfer gene efficiently and some of them can be used for gene transfer into tissue cells in vivo, they suffer from immu…
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Design and Synthesis of Lipids Bearing Nucleosides as Gene Vectors |
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| Man Zhou ZHU,Qi Hua WU,Qing Xiang GUO*.Design and Synthesis of Lipids Bearing Nucleosides as Gene Vectors[J].Chinese Chemical Letters,2001(9). |
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| Authors: | Man Zhou ZHU Qi Hua WU Qing Xiang GUO |
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| Institution: | Man Zhou ZHU,Qi Hua WU,Qing Xiang GUO* Department of Chemistry,University of Science and Technology of China,Hefei 230026 |
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| Abstract: | Some novel lipids bearing nucleosides were designed and synthesized as gene vectors, and the structures of these compounds were characterized by UV, IR, 1HNMR, 13CNMR and elemental analysis. |
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| Keywords: | Gene vector lipid nucleoside synthesis |
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