Synthesis and Relaxometric Properties of Gadolinium(III) Complexes of New Triazine‐Based Polydentate Ligands |
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| Authors: | Lorenzo Tei Marina Benzi Filip Kielar Mauro Botta Camilla Cavallotti Giovanni Battista Giovenzana Silvio Aime |
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| Affiliation: | 1. Dipartimento di Scienze dell'Ambiente e della Vita, Università degli Studi del Piemonte Orientale , ‘A. Avogadro', Viale T. Michel 11, I‐15100 Alessandria (phone: +39‐0131360253;2. fax: +39‐0131360250);3. CAGE Chemicals srl, Via Quarello 11/a, I‐10135 Torino;4. DiSCAFF & DFB Center, Università degli Studi del Piemonte Orientale ‘A. Avogadro', Via Bovio 6, I‐28100 Novara;5. Dipartimento di Chimica IFM and Center of Molecular Imaging, Università degli Studi di Torino, Via Nizza 52, I‐10126 Torino (phone: +39‐0116706451;6. fax: +39‐0116707855) |
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| Abstract: | Two new derivatives based on an s‐triazine structural motif were synthesized by attaching two 2,2′‐hydrazinylidenebis[acetic acid] moieties to the triazine ring to reach an overall heptadenticity for the complexation of lanthanide(III) cations. The remaining reactive site was exploited for the substitution with a functionizable amino group (see H4 L1 ) and a lipophilic moiety (see H4 L2 ). Luminescence‐lifetime determinations revealed the presence of a single H2O molecule coordinated for [Eu( L1 )]. A complete 1H‐NMR relaxometric study was carried out for the octacoordinated [Gd( L1 )] and [Gd( L2 )] complexes. A remarkably long H2O residence lifetime (298τM =5.2 μs) was found by 17O‐NMR in the case of [Gd( L1 )]. Micelle formation of the lipophilic complex [Gd( L2 )] was evidenced, the critical micellization concentration (cmc) determined, and relaxometric properties of the system investigated. |
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| Keywords: | Luminescence Micellisation Gadolinium complexes Triazine ligands Nuclear Magnetic Relaxation Dispersion (NMRD) Relaxometric properties |
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