Lignans from the Bark of Zanthoxylum planispinum |
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| Authors: | Guang‐Zhong Yang Yun Hu Bo Yang Yu Chen |
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| Institution: | 1. Laboratory for Natural Product Chemistry, College of Pharmacy, South Central University for Nationalities, Wuhan 430074, P.?R. China, (phone: +86‐27‐67842689;2. fax: +86‐27‐67842689);3. College of Chemistry and Material Sciences, South Central University for Nationalities, Wuhan 430074, P.?R. China |
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| Abstract: | A new dimeric lignan, named biplanispine A ( 1 ) which represents the first example of a dimeric 2,6‐diaryl‐3,7‐dioxabicyclo3.3.0]octane skeleton from a Rutaceae plant, together with 13 known lignans 2 – 14 , was isolated from the bark of Zanthoxylum planispinum. Their structures were elucidated by spectroscopic methods, especially 2D‐NMR techniques. All isolated compounds were evaluated for their antibacterial activities by the disc diffusion method. Compounds 7 and 9 showed interesting antibacterial activities at 200 μg/disc; they were as effective as kanamycin sulfate at 10 μg/disc against Staphylococcus aureus and Bacillus subtilis. |
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| Keywords: | Zanthoxylum planispinum Lignans Biplanispine A Antibacterial activity |
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