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Irciformonins E – K,C22‐Trinorsesterterpenoids from the Sponge Ircinia formosana |
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| Authors: | Ya‐Ching Shen Pei‐Show Shih Yun‐Sheng Lin Yu‐Chi Lin Yao‐Haur Kuo Yuh‐Chi Kuo Ashraf?Taha Khalil |
| Institution: | 1. School of Pharmacy, College of Medicine, National Taiwan University, Jen‐Ai Rd. Sec. 1, Taipei 100, Taiwan, R.O.C. (phone: +886‐02‐3123456, ext. 2226;2. fax: +886‐02‐23919098);3. Department of Marine Biotechnology and Resources, National Sun Yat‐Sen University, Kaohsiung 804, Taiwan, R.O.C.;4. National Research Institute of Chinese Medicine, Taipei, Taiwan, R.O.C.;5. Department of Life Science, Fu‐Jen University, No.?510, Chung‐Cheng Rd., Hsinchuang 242, Taipei Hsien, Taiwan, R.O.C. |
| Abstract: | Chemical investigation of the sponge Ircinia formosana resulted in the isolation of seven new linear C22‐sesterterpenoids, irciformonins E–K ( 1 – 7 ) in addition to irciformonin A ( 8 ), a previously isolated furanosesterterpenoid (=a furan‐moiety‐containing sesterterpenoid) from the same species. The structures were determined by interpretation of HR‐ESI‐MS and 2D‐NMR spectra. The structure of irciformonin A ( 8 ) was revised. Compound 5 exhibited significant inhibition of peripheral blood mononuclear cell proliferation induced by phytohemaglutinin. |
| Keywords: | Ircinia formosana Sponges Irciformonins A and E – K Sesterterpenoids Furanosesterterpenoid |