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α-环糊精/水杨酸等包络物的NMR自扩散研究
引用本文:彭敏,孔旭新,张惠平,陈群. α-环糊精/水杨酸等包络物的NMR自扩散研究[J]. 波谱学杂志, 2005, 22(2): 141-147
作者姓名:彭敏  孔旭新  张惠平  陈群
作者单位:华东师范大学 物理系,教育部光谱学与波谱学重点实验室,上海 200062
基金项目:上海市纳米科技专项基金,高等学校优秀青年教师教学科研奖励计划
摘    要:
用脉冲梯度场NMR测量自扩散系数的方法研究了水杨酸、水杨酸根、苯酚及苯甲酸根和α-环糊精(α-CD)形成包络物的相互作用. 研究发现4种客体的扩散系数均随着环糊精含量增加而减小. 利用测得的扩散系数计算出了4种客体和环糊精形成包络物的平衡常数,发现平衡常数随空间位阻变小而变大,同时也随着疏水性增强而增大,该结果和2D-ROESY(Rotating Frame Overhauser Effect Spectroscopy)谱均表明,在水杨酸等客体与α-环糊精相互作用过程中,芳香环与环糊精内腔的疏水相互作用起主导作用,不同客体和α-环糊精的结合比均为1∶1.

关 键 词:NMR   梯度场   ROESY   自扩散系数   包络物  
文章编号:1000-4556(2005)02-0141-07
收稿时间:2004-10-14
修稿时间:2004-10-14

Interactions between α-Cyclodextrin and Small Organic Molecules Like Salicylic Acid Studied by NMR Diffusion Measurements
PENG Min,KONG Xu-xin,ZHANG Hui-ping,CHEN Qun. Interactions between α-Cyclodextrin and Small Organic Molecules Like Salicylic Acid Studied by NMR Diffusion Measurements[J]. Chinese Journal of Magnetic Resonance, 2005, 22(2): 141-147
Authors:PENG Min  KONG Xu-xin  ZHANG Hui-ping  CHEN Qun
Affiliation:Analytical Center and the Key Laboratory of Education Ministry for Optics and Magnetic Resonance Spectroscopy,East China Normal University,Shanghai 200062,China
Abstract:
The interactions between α-cyclodextrin and four ligands (salicylic acid, salicylate, phenol and benzoate) was studied by NMR diffusion measurements. The diffusion coefficients of the ligands in the solution, which reflects the affinity of association between α-cyclodextrin and them, were found to decrease as the concentration of α-cyclodextrin increased. Together with 2D-ROESY experiments, it was demonstrated that in forming inclusion complex, the hydrophobic interaction is predominant among various possible interactions between α-cyclodextrin and the ligands.
Keywords:NMR  ROESY
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