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MgI2‐Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies |
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| Authors: | Mathéo Berthet Florian Davanier Dr. Gilles Dujardin Prof. Jean Martinez Dr. Isabelle Parrot |
| Affiliation: | 1. Institut des Biomolécules Max Mousseron, IBMM, UMR‐5247, CNRS, Université Montpellier, ENSCM, CC17‐03, Pl. E. Bataillon, 34095 Montpellier Cedex 5 (France);2. IMMM UMR 6283 CNRS, Université du Maine, Le Mans (France) |
| Abstract: | The scope of MgI2 as a valuable tool for quantitative and mild chemoselective cleavage of protecting groups is described here. This novel synthetic approach expands the use of protecting groups, widens the concept of orthogonality in synthetic processes, and offers a facile opportunity to release compounds from solid supports. |
| Keywords: | carbamates cleavage reactions esters protecting groups solid‐phase synthesis |