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Catalytic Enantioselective Reaction of α‐Phenylthioacetonitriles with Imines Using Chiral Bis(imidazoline)–Palladium Catalysts |
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| Authors: | Masaru Kondo Natsumi Kobayashi Prof?Dr Tsubasa Hatanaka Prof?Dr Yasuhiro Funahashi Prof?Dr Shuichi Nakamura |
| Institution: | 1. Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa‐ku, Nagoya 466‐8555 (Japan), Fax: (+81)?52‐735‐5245;2. Department of Chemistry, Graduate School of Science, Osaka University, 1‐1 Machikaneyama, Toyonaka, Osaka 560‐0043 (Japan) |
| Abstract: | The catalytic enantioselective reaction of α‐phenylthioacetonitriles with imines has been developed. The reaction of various imines proceeds in good yields and diastereo‐ and enantioselectivities in the presence of chiral bis(imidazoline)–palladium catalysts. The obtained products can be converted into β‐aminonitrile or β‐aminoamide compounds without loss of enantiopurity. |
| Keywords: | asymmetric catalysis imidazoline nitriles palladium pincer‐type complexes |