One-pot synthesis of 1,4-disubstituted 1,2,3-triazoles from terminal acetylenes and in situ generated azides |
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| Authors: | Kristin Odlo |
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| Affiliation: | School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo, PO Box 1068, N-0316 Blindern, Oslo, Norway |
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| Abstract: | ![]()
1,4-Disubstituted 1,2,3-triazoles were obtained by a high-yielding copper(I) catalyzed 1,3-dipolar cycloaddition reaction between in situ generated azides and terminal acetylenes. This one-pot, two-step procedure tolerates most functional groups and circumvents the problems associated with the isolation of potentially toxic and explosive organic azides. |
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| Keywords: | One-pot reactions 1,2,3-Triazoles Cycloadditions |
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