Uncatalyzed Michael addition of indoles: synthesis of some novel 3-alkylated indoles via a three-component reaction in solvent-free conditions |
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| Authors: | Mohit L. Deb |
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| Affiliation: | Medicinal Chemistry Division, Regional Research Laboratory, Jorhat 785 006, Assam, India |
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| Abstract: | Synthesis of some novel 3-alkylated indoles via an uncatalyzed Michael addition of indoles using three components in one-pot solvent-free conditions is reported. The mechanism was established by performing the reaction in two steps. The reaction was also studied in different solvents and an important solvent effect was noticed. |
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| Keywords: | Indoles Michael addition Pyrimidines Solvent-free reaction Multicomponent reaction |
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