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Dioxadispiroketal Compounds and a Potential Acyclic Precursor from Amomum aculeatum |
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| Authors: | Salim Angela A Su Bao-Ning Chai Hee-Byung Riswan Soedarsono Kardono Leonardus B S Ruskandi Agus Farnsworth Norman R Swanson Steven M Kinghorn A Douglas |
| Institution: | a Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA b Herbarium Bogoriense, Research Center for Biology, Indonesian Institute of Science, Bogor 16122, Indonesia c Research Center for Chemistry, Indonesian Institute of Science, Tangerang 15310, Indonesia d Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA |
| Abstract: | Four new compounds having an unusual 1,7-dioxadispiro5.1.5.2]-12-ene-11-one tricyclic ring system (1-4), their potential precursor, 5R-hydroxy-1-(4-hydroxyphenyl)-eicosan-3-one (5), and two known compounds, aculeatins A (6) and B (7), have been isolated from Amomum aculeatum. All compounds were characterized by spectroscopic methods and the configurations were established by 2D NOE correlations. Compounds 1-4, 6, and 7 showed cytotoxic activity against several human cancer cell lines. |
| Keywords: | Amomum aculeatum Zingiberaceae Aculeatols A-D Dioxadispiroketals 5R-Hydroxy-1-(4-hydroxyphenyl)-eicosan-3-one NMR data |
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