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Synthesis of chloroquinocin, a pyranonaphthoquinone antibiotic against Gram-positive bacteria |
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| Authors: | Akiko Shimbashi |
| Institution: | Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan |
| Abstract: | Chloroquinocin 1 is an antimicrobial agent against Gram-positive bacteria, including MRSA (methicillin-resistant Staphylococcus aureus). A successful synthesis of 1 was attained through a unique chlorination of the corresponding naphthoquinone derivative 12 as a key step. |
| Keywords: | Chloroquinocin Methicillin-resistant Staphylococcus aureus Antibiotic Gram-positive bacteria Pyranonaphthoquinone Chlorination |
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