A highly regio- and chemoselective addition of carbon nucleophiles to pyrimidinones. A new route to C4 elaborated Biginelli compounds |
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| Authors: | Kamaljit Singh Divya Arora Sukhdeep Singh |
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| Affiliation: | Organic Synthesis Laboratory, Department of Applied Chemical Sciences and Technology, Guru Nanak Dev University, Amritsar 143 005, India |
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| Abstract: | ![]()
Ethyl 6-methyl-pyrimidine-2-one-5-carboxylates react with C-nucleophiles in a diversity oriented synthetic sequence to afford C4 substituted congeners of medicinally potent Biginelli dihydropyrimidinones, in a highly regioselective manner. |
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| Keywords: | Lithiation Biginelli compounds Carbon nucleophiles Regioselective addition |
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